Use of plerixafor to mobilize haematopoietic progenitor cells in healthy donors
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چکیده
منابع مشابه
Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of aging and training.
The number of hematopoietic stem cells (HSC) and endothelial progenitor cells (EPC) is thought to be a marker for neovascularization and vascular repair. Because physical inactivity and aging are risk factors for cardiovascular diseases, these factors may influence the numbers of HSCs and EPCs. Therefore, we examined baseline and exercise-induced levels of HSCs and EPCs in sedentary and trained...
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TET2 is a dioxygenase that catalyses multiple steps of 5-methylcytosine oxidation. Although TET2 mutations frequently occur in various types of haematological malignancies, the mechanism by which they increase risk for these cancers remains poorly understood. Here we show that Tet2-/- mice develop spontaneous myeloid, T- and B-cell malignancies after long latencies. Exome sequencing of Tet2-/- ...
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RA is the prototypic chronic inflammatory disease, characterized by progressive articular cartilage and bone destruction. The systemic nature of RA is evidenced by the increased risk of atherosclerosis and lymphoproliferative disorders. Components of both the innate and adaptive immune system are implicated in the pathophysiology of the articular and extra-articular manifestations of the diseas...
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Granulocyte colony-stimulating factor (G-CSF) mobilized peripheral haematopoietic progenitor cells collected by apheresis (HPC-A) are the most common source used for allogeneic hematopoietic stem cell transplantation (HSCT). Retrospective short and long-term donor follow-up studies show very low risks of serious complications and do not report compelling evidence of increased cancer occurrence....
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Allogeneic transplantation in cancer patients is generally performed with bone marrow (BM) cells collected from the iliac crest of healthy donors under general anesthesia. In the autologous setting, peripheral blood stem cells (PBSCs) are increasingly used for transplantation.'.' They are mobilized from the BM during recovery from chemotherapy orland by treatment with recombinant human (rh) gro...
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ژورنال
عنوان ژورنال: Vox Sanguinis
سال: 2021
ISSN: 0042-9007,1423-0410
DOI: 10.1111/vox.13175